The authors are: Michael J. Rae, Robert N. Butler, Judith Campisi, Aubrey D. N. J. de Grey, Caleb E. Finch, Michael Gough, George M. Martin, Jan Vijg, Kevin M. Perrott, Barbara J. Logan.
The article was published on July, 14. The authors advocate that funding of scientific research is substantailly increased and interventions for aging humans are developed.
Progressive accumulation of aging damage is the physiological cause of numerous age-related pathologies, loss of functionality and increased mortality. Aging places an unprecedented economic and social challenges, as the global increase of medical costs and decreased national workforce's ability. Interventions to to retard, arrest, and even reverse aging damage need to be developed in order to prevent our society from experiencing these catastrophes.
I'd like to pay more attention to the particular research directions. To my mind the authors focused on some really important areas. I put them here in a form of a list, I guess it's better if one adds numbers.
1. Loss of Proliferative Homeostasis: embraces
1.1. age-related hyperplasia (including excessive proliferation of osteoclasts, interstitial fibrosis, and, above all, cancer),
1.2. loss of tissue renewal through stem cell attrition (due, e.g., to cellular senescence, apoptosis)
or atrophy (from systemic endocrinological and signaling changes)
1.3. as well as aberrant differentiation (e.g., accumulation of mesenchymal adipocyte-like cells in aged
tissues, incomplete myocyte development in skeletal muscle, osteoblast-like
differentiation of calcifying vascular smooth muscle cells, adipogenic transformation of
thymic stromal cells in thymic involution, etc)
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